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In addition, the conolidine molecule didn't communicate with the classical receptors, meaning that it wouldn't compete towards opioid peptides to bind to these receptors.In 2011, the Bohn lab noted antinociception in opposition to both of those chemically induced and inflammation-derived discomfort, and experiments indicated deficiency of opioid re

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2015). These reports, taken with each other, advise that, Though a immediate activation of GPR55 or PPAR?? takes place, PEA can make its anti?inflammatory motion in the intestine also through oblique activation of CB1 and CB2 receptors, probably because of the ability of the compound to potentiate the motion of endocannabinoids at these receptors.?

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